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The maximum mechanical stress in brain injuries is experienced far away from the surface of the brain, and at the depth of the sulci, which is also concordant with the neuropathological description of chronic traumatic encephalopathy (CTE), defined by tau phosphorylation deposits in the peri-vascular and sulci regions (Barrio et al., 2015

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Further investigations are required to understand fully the dynamics of AAT oxidation, and the mechanism of action of oxidized AAT